I wanted to test how Pixel Buds did as an option for speakers and microphones for my Zoom calls and Screencast-O-Matic videos. They did fine. They are close to as good as another Bluetooth headset I have. They are not nearly as good a quality as the wired headset I have. They are probably also not quite as good as the Bluetooth headset connecting via Wifi but that is sometimes a sketchy connection for some reason.
The link above has the video if you want to hear how it turned out.